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In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

1 Oct 1993

Abstract excerpt

Recent genetic experiments have suggested that tat transactivation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat requires functional upstream enhancer sequences--Sp1 sites, in particular. In these experiments, HeLa cell nuclear extracts were passed over affinity matrices containing chemically synthesized or bacterially expressed HIV-1 Tat. Assay of material that bound to and eluted from...

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PMID: 7690421
DOI: 10.1128/jvi.67.10.6224-6233.1993

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