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Article

Identification of QTL genes for BMD variation using both linkage and gene-based association approaches.

Human genetics - 1 Oct 2011

Li Gloria Hoi-Yee, Cheung Ching-Lung, Xiao Su-Mei, Lau Kam-Shing, Gao Yi, Bow Cora H, Huang Qing-Yang, Sham Pak-Chung, Kung Annie Wai-Chee

Abstract excerpt

Low bone mineral density (BMD) is a risk factor for osteoporotic fracture with a high heritability. Previous large scale linkage study in Northern Chinese has identified four significant quantitative trait loci (QTL) for BMD variation on chromosome 2q24, 5q21, 7p21 and 13q21. We performed a replication study of these four QTL in 1,459 Southern Chinese from 306 pedigrees. Successful replication was observed on...

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Identifiers

PMID: 21424381
DOI: 10.1007/s00439-011-0972-2
PMCID: PMC3178777

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ERAP1

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