Continuous Transforming Growth Factor β ₁ Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte Redifferentiation

Abstract excerpt

One of the most important factors in the production of cartilage is transforming growth factor beta1 (TGF-beta1). To obtain sustained release of TGF-beta1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-beta1 gene. The single clone derivative showed sustained TGF-beta1 secretion. It also showed constitutive type II collagen expression....

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