Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1.

BMC musculoskeletal disorders - 10 Jun 2015

Yoon Hyun Joo, Kim Suk Bum, Somaiya Dhara, Noh Moon Jong, Choi Kyoung-Baek, Lim Chae-Lyul, Lee Hyeon-Youl, Lee Yeon-Ju, Yi Youngsuk, Lee Kwan Hee

Abstract excerpt

BACKGROUND: A localized non-surgical delivery of allogeneic human chondrocytes (hChonJ) with irradiated genetically modified chondrocytes (hChonJb#7) expressing transforming growth factor-β1 (TGF-β1) showed efficacy in regenerating cartilage tissue in our pre-clinical studies and human Phase I and II clinical trials. These previous observations led us to investigate the molecular mechanisms of the cartilage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chondrogenesis

Share to Collagen Type II

Share to Glycosaminoglycans

Share to Hep G2 Cells

Share to Regeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 26059549
DOI: 10.1186/s12891-015-0599-x
PMCID: PMC4460646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1.PMID 26059549Read ↗

Effects of TGF-β Overexpression via rAAV Gene Transfer on the Early Repair Processes in an Osteochondral Defect Model in MinipigsSemantic proximity Read ↗

Effect of adenovirus-mediated TGF-β1 gene transfer on the function of rabbit articular chondrocytes.Semantic proximity Read ↗

Clinical potential and challenges of using genetically modified cells for articular cartilage repairSemantic proximity Read ↗

Cartilage Tissue Engineering: Recent Advances and Perspectives from Gene Regulation/TherapySemantic proximity Read ↗

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the kneeSemantic proximity Read ↗

Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destructionSemantic proximity Read ↗

Improvement of the Chondrocyte-Specific Phenotype upon Equine Bone Marrow Mesenchymal Stem Cell Differentiation: Influence of Culture Time, Transforming Growth Factors and Type I Collagen siRNAs on the Differentiation Index.Semantic proximity Read ↗

Heparin-based self-assembling peptide scaffold reestablish chondrogenic phenotype of expanded de-differentiated human chondrocytes.Semantic proximity Read ↗

Continuous Transforming Growth Factor β <sub>1</sub> Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte RedifferentiationSemantic proximity Read ↗

Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors.Semantic proximity Read ↗

TGF-β2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions.Semantic proximity Read ↗

[Biomaterials and cell therapy in cartilage disorders].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.