Article
A mixed co-culture of mesenchymal stem cells and transgenic chondrocytes in alginate hydrogel for cartilage tissue engineering.
Journal of tissue engineering and regenerative medicine - 1 Jan 2015
Zhang Feng, Su Kai, Fang Yu, Sandhya Swaminathan, Wang Dong-An
Abstract excerpt
To regenerate articular cartilage tissue from degeneration and trauma, synovial mesenchymal stem cells (SMSCs) were used in this study as therapeutic progenitor cells to induce therapeutic chondrogenesis. To accomplish this, chondrocytes pre-transduced with adenoviral vectors carrying the transforming growth factor (TGF) β3 gene were selected as transgenic companion cells and co-cultured side-by-side with SMSCs...
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