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Article

Gene Transfer and Gene Silencing in Stem Cells to Promote Chondrogenesis.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Zhang Feng, Wang Dong-An

Abstract excerpt

In stem cell-based chondrogenesis for articular cartilage regeneration, TGF-β3 is dosed to the stem cells to drive differentiation into chondrocytic cells. Meanwhile, type I collagen, which is endogenously expressed in some stem cells (e.g., synovium-derived mesenchymal stem cells) and upregulated by TGF-β3, poses a threat to chondrogenesis, as type I collagen may alter the components and stiffness of articular...

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PMID: 26445833
DOI: 10.1007/978-1-4939-2938-2_7

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