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Article

Advances and challenges in gene‐based approaches for osteoarthritis

5 Sept 2013

Abstract excerpt

Osteoarthritis (OA), a paramount cause of physical disability for which there is no definitive cure, is mainly characterized by the gradual loss of the articular cartilage. Current nonsurgical and reconstructive surgical therapies have not met success in reversing the OA phenotype so far. Gene transfer approaches allow for a long-term and site-specific presence of a therapeutic agent to re-equilibrate the...

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PMID: 24006099
DOI: 10.1002/jgm.2741

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