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Article

Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2.

Cancer research - 1 May 2006

Wu Joyce, Lee Cathy, Yokom Daniel, Jiang Helen, Cheang Maggie C U, Yorida Erika, Turbin Dmitry, Berquin Isabelle M, Mertens Peter R, Iftner Thomas, Gilks C Blake, Dunn Sandra E

Abstract excerpt

The overexpression of the epidermal growth factor receptor (EGFR) and HER-2 underpin the growth of aggressive breast cancer; still, it is unclear what governs the regulation of these receptors. Our laboratories recently determined that the Y-box binding protein-1 (YB-1), an oncogenic transcription/translation factor, induced breast tumor cell growth in monolayer and in soft agar. Importantly, mutating YB-1 at...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16651443
DOI: 10.1158/0008-5472.CAN-05-3561

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the Y-box binding protein-1 results in suppression of the epidermal growth factor receptor and HER-2.PMID 16651443Read ↗

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