Article
Effects of excision repair cross-complementation group 1 (ERCC1) single nucleotide polymorphisms on the prognosis of non-small cell lung cancer patients.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2010
Takenaka Tomoyoshi, Yano Tokujiro, Kiyohara Chikako, Miura Naoko, Kouso Hidenori, Ohba Taro, Kometani Takuro, Shoji Fumihiro, Yoshino Ichiro, Maehara Yoshihiko
Abstract excerpt
BACKGROUND: Excision repair cross-complementation group 1 (ERCC1) is the lead enzyme in the nucleotide excision repair process. Two polymorphisms of ERCC1, T19007C (rs11615) and C8092A (rs3212986), have been reported to affect both the carcinogenesis and the survival of the patients who received platinum-based chemotherapy, but the mechanism by which these polymorphisms influence the survival is unclear. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
