Article
The determination of relationship between "excision repair cross-complementing group 1" (ERCC1) gene T19007C and C8092A single nucleotide polymorphisms and clinicopathological parameters in non-small cell lung cancer.
Molecular biology reports - 1 Jan 2012
Koç Esin, Caner Vildan, Büyükpınarbaşılı Nur, Tepeli Emre, Türk Nilay Sen, Ozan Çetin G, Bağcı Gülseren
Abstract excerpt
DNA repair plays a key role in prevention of carcinogenesis and one of the most important DNA repair mechanisms is nucleotide excision repair (NER) pathway. This pathway includes a number of genes such as excision repair cross-complementing group 1 (ERCC1) gene which are responsible for the 5' incision of damaged DNA. A reduced DNA repair capacity associated with ERCC1 mRNA level has been observed in lung...
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