Article
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
Nature communications - 14 Nov 2019
Schewe Julia, Seidel Eric, Forslund Sofia, Marko Lajos, Peters Jörg, Muller Dominik N, Fahlke Christoph, Stölting Gabriel, Scholl Ute
Abstract excerpt
Gain-of-function mutations in the chloride channel ClC-2 were recently described as a cause of familial hyperaldosteronism type II (FH-II). Here, we report the generation of a mouse model carrying a missense mutation homologous to the most common FH-II-associated CLCN2 mutation. In these Clcn2R180Q/+ mice, adrenal morphology is normal, but Cyp11b2 expression and plasma aldosterone levels are elevated. Male...
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