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Selection of functional human antibodies from retroviral display libraries

23 Feb 2005

Abstract excerpt

Antibody library technology represents a powerful tool for the discovery and design of antibodies with high affinity and specificity for their targets. To extend the technique to the expression and selection of antibody libraries in an eukaryotic environment, we provide here a proof of concept that retroviruses can be engineered for the display and selection of variable single-chain fragment (scFv) libraries. A...

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PMID: 15731328
DOI: 10.1093/nar/gni033

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