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Article

Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

Genes and immunity - 1 May 2005

Kosoy R, Concannon P

Abstract excerpt

Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk for autoimmune diabetes in the NOD mouse, these variants were tested for allelic association with type 1 diabetes (T1D) in a family based study. Alleles at markers in the TAB2/SUMO4 locus on chromosome 6q had been previously reported to...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Diabetes Mellitus, Type 1
Share to NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-kappa B p50 Subunit

Share to Promoter Regions, Genetic

Share to Sequence Deletion

Share to Small Ubiquitin-Related Modifier Proteins

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Source

Identifiers

PMID: 15729364
DOI: 10.1038/sj.gene.6364174

Genes

SUMO4
TAB2
NFKB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.PMID 15729364Read ↗

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