A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

doi:10.1038/ng1391

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Article

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Nature genetics - 1 Aug 2004

Guo Dehuang, Li Manyu, Zhang Yan, Yang Ping, Eckenrode Sarah, Hopkins Diane, Zheng Weipeng, Purohit Sharad, Podolsky Robert H, Muir Andrew, Wang Jinzhao, Dong Zheng, Brusko Todd, Atkinson Mark, Pozzilli Paolo, Zeidler Adina, Raffel Leslie J, Jacob Chaim O, Park Yongsoo, Serrano-Rios Manuel, Larrad Maria T Martinez, Zhang Zixin, Garchon Henri-Jean, Bach Jean-Francois, Rotter Jerome I, She Jin-Xiong, Wang Cong-Yi

Abstract excerpt

Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been challenging and largely limited to known candidate genes. Here, we report evidence for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval. We cloned a new gene (SUMO4),...

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Identifiers

PMID: 15247916
DOI: 10.1038/ng1391

Genes

SUMO4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.PMID 15247916Read ↗

Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.Semantic proximity Read ↗

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Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

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Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes.Semantic proximity Read ↗

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A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.Semantic proximity Read ↗

Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.Semantic proximity Read ↗

Small ubiquitin-like modifier-4 Met55Val polymorphism is associated with glycemic control of Type 2 diabetes mellitus in Taiwan.Semantic proximity Read ↗

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