Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients.

Annals of the New York Academy of Sciences - 1 Oct 2006

Sedimbi Saikiran K, Shastry Arun, Park Yongsoo, Rumba Ingrida, Sanjeevi Carani B

Abstract excerpt

Small ubiquitin-related modifier (SUMO4), located in IDDM5, has been identified as a potential susceptibility gene for type 1 diabetes mellitus (T1DM). The novel polymorphism M55V, causing an amino acid change in the evolutionarily conserved met55 residue has been shown to activate the nuclear factor kappaB (NF-kappaB), hence the suspected role of SUMO4 in the pathogenicity of T1DM. The M55V polymorphism has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Infant

Share to Latvia

Share to Methionine

Share to Polymorphism, Restriction Fragment Length

Share to Small Ubiquitin-Related Modifier Proteins

Source

Identifiers

PMID: 17130565
DOI: 10.1196/annals.1375.041

Genes

SUMO4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients.PMID 17130565Read ↗

No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients.Semantic proximity Read ↗

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.Semantic proximity Read ↗

No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects.Semantic proximity Read ↗

Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with susceptibility to autoimmune and inflammatory diseases: a meta-analysis.Semantic proximity Read ↗

SUMO4 and its role in type 1 diabetes pathogenesis.Semantic proximity Read ↗

Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.Semantic proximity Read ↗

Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.Semantic proximity Read ↗

Sumoylation Modulates the Susceptibility to Type 1 Diabetes.Semantic proximity Read ↗

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.