Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.

Annals of the New York Academy of Sciences - 1 Oct 2006

Wang Cong-Yi, Podolsky Robert, She Jin-Xiong

Abstract excerpt

Genomewide linkage analyses since the early 1990s suggested over 20 genomic intervals that may contain susceptibility genes for type 1 diabetes. However, the identification of the specific genes in these intervals presents a formidable challenge due to a number of difficulties associated with genetic mapping and cloning of genes implicated in complex diseases. One of the difficulties is due to the presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Chromosomes, Human, Pair 6
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forecasting

Share to Genetic Heterogeneity

Share to Physical Chromosome Mapping

Share to Reproducibility of Results

Share to Small Ubiquitin-Related Modifier Proteins

Source

Identifiers

PMID: 17130563
DOI: 10.1196/annals.1375.039

Genes

SUMO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.PMID 17130563Read ↗

SUMO4 and its role in type 1 diabetes pathogenesis.Semantic proximity Read ↗

Sumoylation Modulates the Susceptibility to Type 1 Diabetes.Semantic proximity Read ↗

Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.Semantic proximity Read ↗

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes.Semantic proximity Read ↗

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.Semantic proximity Read ↗

Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.Semantic proximity Read ↗

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.Semantic proximity Read ↗

A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.