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Article

SUMO4 and its role in type 1 diabetes pathogenesis.

Diabetes/metabolism research and reviews - 1 Feb 2008

Wang Cong-Yi, She Jin-Xiong

Abstract excerpt

Susceptibility to type 1 diabetes (T1D) is determined by interactions of multiple genes with unknown environmental factors. Despite the characterization of over 20 susceptibility regions for T1D, identification of specific genes in these regions is still a formidable challenge. In 2004, we first reported the cloning of a novel, small ubiquitin-like modifier (SUMO) gene, SUMO4, in the IDDM5 interval on chromosome...

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Source

Identifiers

PMID: 17990297
DOI: 10.1002/dmrr.797

Genes

SUMO4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SUMO4 and its role in type 1 diabetes pathogenesis.PMID 17990297Read ↗

Sumoylation Modulates the Susceptibility to Type 1 Diabetes.Semantic proximity Read ↗

Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene.Semantic proximity Read ↗

Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.Semantic proximity Read ↗

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.Semantic proximity Read ↗

Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

Analyses of multiple single-nucleotide polymorphisms in the SUMO4/IDDM5 region in affected sib-pair families with type I diabetes.Semantic proximity Read ↗

Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes.Semantic proximity Read ↗

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.Semantic proximity Read ↗

[Association between SUMO4 polymorphisms and type 2 diabetes mellitus].Semantic proximity Read ↗

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.Semantic proximity Read ↗

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