Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.

The Journal of biological chemistry - 26 Sept 2008

Hasler Udo, Nunes Paula, Bouley Richard, Lu Hua A J, Matsuzaki Toshiyuki, Brown Dennis

Abstract excerpt

The unique phenotype of renal medullary cells allows them to survive and functionally adapt to changes of interstitial osmolality/tonicity. We investigated the effects of acute hypertonic challenge on AQP2 (aquaporin-2) water channel trafficking. In the absence of vasopressin, hypertonicity alone induced rapid (<10 min) plasma membrane accumulation of AQP2 in rat kidney collecting duct principal cells in situ,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aquaporin 2
Share to Biological Transport, Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Tubules, Collecting

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Osmotic Pressure

Share to p38 Mitogen-Activated Protein Kinases

Share to Vasopressins

Source

Open in PubMed Open full text

Identifiers

PMID: 18664568
DOI: 10.1074/jbc.M801071200
PMCID: PMC2546545

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells.PMID 18664568Read ↗

Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells.Semantic proximity Read ↗

Ser-256 phosphorylation dynamics of Aquaporin 2 during maturation from the ER to the vesicular compartment in renal cells.Semantic proximity Read ↗

Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells.Semantic proximity Read ↗

Novel signalling pathways in nephrogenic syndrome of inappropriate antidiuresis: functional implication of site-specific AQP2 phosphorylation.Semantic proximity Read ↗

Characterization of the putative phosphorylation sites of the AQP2 C terminus and their role in AQP2 trafficking in LLC-PK1 cells.Semantic proximity Read ↗

Modulation of Na+,K+-ATPase activity is of importance for RVD.Semantic proximity Read ↗

The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation.Semantic proximity Read ↗

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.Semantic proximity Read ↗

Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus.Semantic proximity Read ↗

TRiPPing the sensors: The osmosensing pathway of Polycystin 2Semantic proximity Read ↗

Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress.Semantic proximity Read ↗

Osmotic stimulation of the Na+/H+ exchanger NHE1: relationship to the activation of three MAPK pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.