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Article

Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005

Block Matthew S, Mendez-Fernandez Yanice V, Van Keulen Virginia P, Hansen Michael J, Allen Kathleen S, Taboas Anya L, Rodriguez Moses, Pease Larry R

Abstract excerpt

Natural selection drives diversification of MHC class I proteins, but the mechanism by which selection for polymorphism occurs is not known. New variant class I alleles differ from parental alleles both in the nature of the CD8 T cell repertoire formed and the ability to present pathogen-derived peptides. In the current study, we examined whether T cell repertoire differences, Ag presentation differences, or both...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15728484
DOI: 10.4049/jimmunol.174.5.2756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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