Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway

23 Feb 2005

Abstract excerpt

The small GTPases of the Rho family are key intermediates in cellular signalling triggered by activated cell-adhesion receptors. In this study, we took advantage of RNA interference (RNAi) using small interfering RNAs (siRNAs) to define the roles of the best-characterized members of the RhoGTPase family, RhoA, Rac1 and Cdc42, in the control of MMP-1, MMP-2 and type-I-collagen expression in normal human skin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15728253
DOI: 10.1242/jcs.01707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathwayPMID 15728253Read ↗

Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype.Semantic proximity Read ↗

Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblastsSemantic proximity Read ↗

Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.Semantic proximity Read ↗

Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.Semantic proximity Read ↗

Signaling role of Cdc42 in regulating mammalian physiology.Semantic proximity Read ↗

Transcriptional regulation of the small GTPase RhoB gene by TGFß‐induced signaling pathwaysSemantic proximity Read ↗

MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin CytoskeletonSemantic proximity Read ↗

Rac inhibition reverses the phenotype of fibrotic fibroblasts.Semantic proximity Read ↗

Integrin-mediated signals regulated by members of the rho family of GTPases.Semantic proximity Read ↗

Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes.Semantic proximity Read ↗

Cdc42 in oncogenic transformation, invasion, and tumorigenesis.Semantic proximity Read ↗

Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.