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Article

Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Feb 2012

Novakofski Kira D, Torre Christopher J, Fortier Lisa A

Abstract excerpt

Small GTPase proteins mediate changes in cellular morphology and other cellular functions. The aim of this study was to examine signaling of the small GTPase Cdc42 by stimulating chondrocytes grown in monolayer with long- (96 h) or short- (2 and 30 min) term exposure to interleukin-1α (IL-1α), IL-6, or IL-8. Quantitative PCR was used to determine changes in collagen type IIB (COL2A1), aggrecan (AGG), and matrix...

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PMID: 21809384
DOI: 10.1002/jor.21515

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