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Article

SHARE: an adaptive algorithm to select the most informative set of SNPs for candidate genetic association.

Biostatistics (Oxford, England) - 1 Oct 2009

Dai James Y, Leblanc Michael, Smith Nicholas L, Psaty Bruce, Kooperberg Charles

Abstract excerpt

Association studies have been widely used to identify genetic liability variants for complex diseases. While scanning the chromosomal region 1 single nucleotide polymorphism (SNP) at a time may not fully explore linkage disequilibrium, haplotype analyses tend to require a fairly large number of parameters, thus potentially losing power. Clustering algorithms, such as the cladistic approach, have been proposed to...

Topics

Aged
Algorithms
Biostatistics
Female
Genome-Wide Association Study
Haplotypes
Humans
Linkage Disequilibrium
Lipoproteins
Middle Aged
Models, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Regression Analysis

Venous Thrombosis

Source

Open in PubMed Open full text

Identifiers

PMID: 19605740
DOI: 10.1093/biostatistics/kxp023
PMCID: PMC2742496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19605740-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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