Clustering of haplotypes based on phylogeny: how good a strategy for association testing?

Abstract excerpt

Haplotypes are now widely used in association studies between markers and disease susceptibility locus. However, when a large number of markers are considered, the number of possible haplotypes increases leading to two problems: an increased number of degrees of freedom that may result in a lack of power and the existence of rare haplotypes that may be difficult to take into account in the statistical analysis....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Data Interpretation, Statistical