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Article

TLR2 Arg677Trp polymorphism in leprosy: revisited.

Human genetics - 1 Apr 2005

Malhotra Dheeraj, Relhan Vineet, Reddy B S N, Bamezai Ramesh

Abstract excerpt

We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene....

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Identifiers

PMID: 15726416
DOI: 10.1007/s00439-004-1249-9

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TLR2

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