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Article

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Clinical and diagnostic laboratory immunology - 1 May 2004

Ben-Ali Meriem, Barbouche Mohamed-Ridha, Bousnina Soufia, Chabbou Abdellatif, Dellagi Koussay

Abstract excerpt

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

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Identifiers

PMID: 15138193
DOI: 10.1128/CDLI.11.3.625-626.2004
PMCID: PMC404573

Genes

TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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