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Article

Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling.

Journal of biology - 1 Jan 2005

Itoh Keiji, Brott Barbara K, Bae Gyu-Un, Ratcliffe Marianne J, Sokol Sergei Y

Abstract excerpt

BACKGROUND: Dishevelled (Dsh) is a key component of multiple signaling pathways that are initiated by Wnt secreted ligands and Frizzled receptors during embryonic development. Although Dsh has been detected in a number of cellular compartments, the importance of its subcellular distribution for signaling remains to be determined. RESULTS: We report that Dsh protein accumulates in cell nuclei when Xenopus...

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Identifiers

PMID: 15720724
DOI: 10.1186/jbiol20
PMCID: PMC551520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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