Article
Molecular genetics of diabetes mellitus.
Bailliere's clinical endocrinology and metabolism - 1 Jul 1995
Aitman T J, Todd J A
Abstract excerpt
As a result of advances in technology, genome searches have been carried out for susceptibility genes for type 1 diabetes in humans and in the NOD mouse. These have shown that, in the NOD mouse, diabetes susceptibility is under the control of at least ten separate chromosomal loci. In the human, in addition to HLA and INS, two new susceptibility genes have been localized, IDDM4 on chromosome 11q and IDDM5 on 6q,...
Topics
- Adult
- Animals
- Diabetes Mellitus
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Glucokinase
- HLA Antigens
- Humans
- Insulin
- Mice
- Mice, Inbred NOD
- Mutation