Article
Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients.
Shock (Augusta, Ga.) - 1 Mar 2005
Upperman Jeffrey S, Pillage Gina, Siddiqi Muhammad Q, Zeevi Adriana, Kelly Natasha, Ford Henri R, Kammerer Candace, Spolarics Zoltán
Abstract excerpt
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a condition associated with malaria resistance, is a common genetic polymorphism. Decreased interleukin (IL)-10 production was demonstrated in vivo and in vitro in the African and Mediterranean forms of G6PD deficiencies. We hypothesized that low-producing IL-10 alleles are more abundant in the G6PD-deficient than nondeficient population. One hundred eleven men...
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