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Article

Contrasting effects of butyrate on the expression of phenotypic markers of differentiation in neoplastic and non-neoplastic colonic epithelial cells in vitro.

Journal of gastroenterology and hepatology - 1 Jan 2000

Gibson P R, Moeller I, Kagelari O, Folino M, Young G P

Abstract excerpt

The in vitro effect of butyrate on expression of differentiation markers in colonic epithelial cells was assessed in the colon cancer cell line, LIM1215 and in epithelial cells isolated from a surgically resected histologically normal colon. Markers used to assess cell differentiation were: net glycoprotein synthesis ([3H]-glucosamine uptake) expressed relative to net protein synthesis ([14C]-leucine uptake), and...

Topics

Butyrates
Butyric Acid
Cell Line
Cell Survival
Cell Transformation, Neoplastic
Colonic Neoplasms
DNA, Neoplasm
Epithelium
Glycoproteins
Humans
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tumor Cells, Cultured

Source

Identifiers

PMID: 1571499
DOI: 10.1111/j.1440-1746.1992.tb00956.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1571499-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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