Article
Effects of 1,25-dihydroxyvitamin D3 and its analogs on butyrate-induced differentiation of HT-29 human colonic carcinoma cells and on the reversal of the differentiated phenotype.
Archives of biochemistry and biophysics - 1 Feb 1990
Tanaka Y, Bush K K, Eguchi T, Ikekawa N, Taguchi T, Kobayashi Y, Higgins P J
Abstract excerpt
1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) greatly enhances sodium butyrate (NaB)-induced enterocyte differentiation of HT-29 human colonic carcinoma cells while 1,25-(OH)2D3 alone induces growth restriction without associated differentiation. In the present study, the efficacies of various analogs...
Topics
- Butyrates
- Butyric Acid
- Calcitriol
- Cell Differentiation
- Cell Line
- Colonic Neoplasms
- Humans
- Kinetics
- Molecular Structure
- Mucins
- Phenotype
- Structure-Activity Relationship
- Tumor Cells, Cultured