Article
Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis.
Structure (London, England : 1993) - 1 Feb 2004
Brink Jacob, Ludtke Steven J, Kong Yifei, Wakil Salih J, Ma Jianpeng, Chiu Wah
Abstract excerpt
Fatty acid synthase (FAS) is a 550 kDa homodimeric enzyme with multiple functional and structural domains. Normal mode analysis of a previously determined 19 A structure of FAS suggested that this enzyme might assume different conformational states with several distinct hinge movements. We have used a simultaneous multiple-model refinement method to search for the presence of the structural conformers from the...
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