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Article

Promoter Analysis and Aberrant Expression of the MUC5B Gene in Diffuse Panbronchiolitis

11 Feb 2005

Abstract excerpt

Diffuse panbronchiolitis (DPB) is a chronic inflammatory airway disease predominantly affecting Asian populations. DPB is considered to be a complex genetic disease. Considering the mucous hypersecretion of the disease, we hypothesized that the transcriptional activity of mucin genes may be altered in DPB. We analyzed nucleotide sequences of regulatory region of six mucin genes--MUC1, MUC2, MUC4, MUC5AC, MUC5B,...

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PMID: 15709052
DOI: 10.1164/rccm.200409-1168oc

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