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Interaction between the promoterMUC5Bpolymorphism and mucin expression: is there a difference according to ILD subtype?

24 Jun 2020

Abstract excerpt

TheMUC5Bpromoter variant rs35705950 is associated with idiopathic pulmonary fibrosis (IPF). MUC5B glycoprotein is overexpressed in IPF lungs. We examined immunohistochemical expression of MUC5B in different interstitial lung disease patterns according to rs35705950 T-allele carriage. We observed increased expression of MUC5B in T-allele carriers in both distal airways and honeycomb cysts in patients with IPF...

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PMID: 32580994
DOI: 10.1136/thoraxjnl-2020-214579

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