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Article

Establishment of a subgenomic replicon for bovine viral diarrhea virus in Huh-7 cells and modulation of interferon-regulated factor 3-mediated antiviral response.

Journal of virology - 1 Mar 2005

Horscroft Nigel, Bellows Dan, Ansari Israrul, Lai Vicky C H, Dempsey Shannon, Liang Delin, Donis Ruben, Zhong Weidong, Hong Zhi

Abstract excerpt

We describe the development of a selectable, bi-cistronic subgenomic replicon for bovine viral diarrhea virus (BVDV) in Huh-7 cells, similar to that established for hepatitis C virus (HCV). The selection marker and reporter (Luc-Ubi-Neo) in the BVDV replicon was fused with the amino-terminal protease N(pro), and expression of the nonstructural proteins (NS3 to NS5B) was driven by an encephalomyocarditis virus...

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Identifiers

PMID: 15708997
DOI: 10.1128/JVI.79.5.2788-2796.2005
PMCID: PMC548457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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