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Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening

30 Sept 2024

Abstract excerpt

Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis has been hampered by the lack of a reverse genetics (RG) system in the past. Since 2017, multiple plasmid-based RG systems for simian, human, and murine-like rotaviruses have been established. However, none of the described methods have supported the recovery of bovine rotaviruses (BRVs). Here, we established an optimized...

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PMID: 39349279
DOI: 10.1016/j.virs.2024.09.010

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