Article
Hepatitis C virus and the related bovine viral diarrhea virus considerably differ in the functional organization of the 5' non-translated region: implications for the viral life cycle.
Virology - 15 Mar 2005
Grassmann Claus Wilhelm, Yu Haiying, Isken Olaf, Behrens Sven-Erik
Abstract excerpt
The 5' non-translated regions (5'NTRs) of hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV) initiate translation of the viral RNA genome through an internal ribosomal entry site (IRES) and operate as major determinants of the RNA replication cycle. We report on comparative studies with both virus systems demonstrating that the functional organization of the 5'NTRs of HCV and BVDV shows evident...
Topics
- 5' Untranslated Regions
- Animals
- Base Sequence
- Cattle
- Diarrhea Viruses, Bovine Viral
- Genome, Viral
- Hepacivirus
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation