Early Antiretroviral Therapy for Simian Immunodeficiency Virus Infection Leads to Mucosal CD4⁺T-Cell Restoration and Enhanced Gene Expression Regulating Mucosal Repair and Regeneration

Abstract excerpt

Simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV) infections lead to rapid depletion of CD4(+) T cells from gut-associated lymphoid tissue (GALT). Although the administration of antiretroviral therapy (ART) has been shown to increase CD4(+) T-cell levels in the peripheral blood in both SIV and HIV infections, its efficacy in restoring intestinal mucosal CD4(+) T cells has not been well...

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