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Article

Gastrointestinal Tract as a Major Site of CD4 <sup>+</sup> T Cell Depletion and Viral Replication in SIV Infection

17 Apr 1998

Abstract excerpt

Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4+ T cells in the intestine occurred coincident with...

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PMID: 9545219
DOI: 10.1126/science.280.5362.427

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