Article
Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans.
Aging cell - 1 Apr 2005
Houthoofd Koen, Fidalgo Manuel A, Hoogewijs David, Braeckman Bart P, Lenaerts Isabelle, Brys Kristel, Matthijssens Filip, De Vreese Annemie, Van Eygen Sylvie, Muñoz Manuel J, Vanfleteren Jacques R
Abstract excerpt
The insulin/insulin-like growth factor-1 (Ins/IGF-1) pathway regulates the aging rate of the nematode Caenorhabditis elegans. We describe other features of the three Ins/IGF-1 mutants daf-2, age-1 and aap-1. We show that the investigated Ins/IGF-1 mutants all have a reduced body volume, reduced reproductive capacity, increased ATP concentrations and an elevated stress resistance. We also observed that heat...
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