Article
Coronary artery and orifice development is associated with proper timing of epicardial outgrowth and correlated Fas-ligand-associated apoptosis patterns.
Circulation research - 18 Mar 2005
Eralp Ismail, Lie-Venema Heleen, DeRuiter Marco C, van den Akker Nynke M S, Bogers Ad J J C, Mentink Monica M T, Poelmann Robert E, Gittenberger-de Groot Adriana C
Abstract excerpt
The proepicardial organ provides differentiated cell types to the myocardial wall and facilitates coronary development. Ingrowth of the coronary arteries into the aorta has recently been linked to apoptosis. This study was set up to examine the effect of an inhibition of epicardial outgrowth on apoptotic patterning and coronary development. Epicardial outgrowth was blocked at HH15-17 in quail embryos, which...
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