Article

Endocardial-mesenchymal transition underlies fusion of the conotruncal ridges during normal and bicuspid aortic valve development

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>Right-left bicuspid aortic valve (R-L BAV) is the most frequent phenotype of the most common congenital heart disease. Its etiology is based on two associated morphogenetic defects during cardiac outflow tract (OFT) septation: abnormal migration of cardiac neural crest (CNC) cells, and excessive fusion of the conotruncal ridges (CRs). The aim of this study is to elucidate the mechanism...

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Literature Corpus work: 4b37abf0-07b5-57d5-8c16-b9323ad8f9b4
DOI: 10.21203/rs.3.rs-4999094/v1

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