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Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors

15 Jun 2005

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated in diverse human tumors and may play a direct role in malignant transformation. However, the full complement of target genes that STAT3 regulates to promote oncogenesis is not known. We created a system to express a constitutively active form of STAT3, STAT3-C, in mouse fibroblasts and used it to identify STAT3...

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PMID: 15958548
DOI: 10.1158/0008-5472.can-04-4281

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