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Article

The affinity of protein C for the thrombin.thrombomodulin complex is determined in a primary way by active site-dependent interactions.

The Journal of biological chemistry - 15 Apr 2005

Lu Genmin, Chhum Sotheavy, Krishnaswamy Sriram

Abstract excerpt

The interaction of thrombin (IIa) with thrombomodulin (TM) is essential for the efficient activation of protein C (PC). Interactions between PC and extended surfaces, likely contributed by TM within the IIa.TM complex, have been proposed to play a key role in PC activation. Initial velocities of PC activation at different concentrations of PC and TM could be accounted for by a model that did not require...

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PMID: 15705565
DOI: 10.1074/jbc.M500881200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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