Article
Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.
Respiratory physiology & neurobiology - 15 Feb 2005
Oyamada Yoshitaka, Yamaguchi Kazuhiro, Murai Michie, Hakuno Haruhiko, Ishizaka Akitoshi
Abstract excerpt
In order to determine the role of Kir2.2 in the hypercapnic ventilatory response (HCVR) during postnatal development, we measured the response of the Kir2.2-knockout (Kir2.2-/-) mouse in an unanesthetized unrestrained state by means of pressure plethysmography on postnatal days 9-10, 14-15 and 18, and compared the response with that in its wild counterpart, the FVB mouse. We also examined developmental changes in...
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