Article
Impaired cardiorespiratory responses to hypercapnia in neonatal mice lacking PAC1 but not VPAC2 receptors.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Feb 2021
Barrett Karlene T, Hasan Shabih U, Scantlebury Morris H, Wilson Richard J A
Abstract excerpt
The evidence is mounting for a role for abnormal signaling of the stress peptide pituitary adenylate cyclase activating polypeptide (PACAP) and its canonical receptor PAC1 in the pathogenesis of sudden infant death syndrome. In this study, we investigated whether the PACAP receptors PAC1 or VPAC2 are involved in the neonatal cardiorespiratory response to hypercapnic stress. We used head-out plethysmography and...
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