Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome.

American journal of respiratory and critical care medicine - 15 Nov 2021

Madani Amélia, Pitollat Gabriel, Sizun Eléonore, Cardoit Laura, Ringot Maud, Bourgeois Thomas, Ramanantsoa Nelina, Delclaux Christophe, Dauger Stéphane, d'Ortho Marie-Pia, Thoby-Brisson Muriel, Gallego Jorge, Matrot Boris

Abstract excerpt

Rationale: Congenital central hypoventilation syndrome (CCHS) is characterized by life-threatening sleep hypoventilation and is caused by PHOX2B gene mutations, most frequently the PHOX2B27Ala/+ mutation, with patients requiring lifelong ventilatory support. It is unclear whether obstructive apneas are part of the syndrome. Objectives: To determine if Phox2b27Ala/+ mice, which present the main symptoms of CCHS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Hypoventilation

Share to Mutation

Share to Sleep Apnea, Central

Share to Transcription Factors

Source

Identifiers

PMID: 34478357
DOI: 10.1164/rccm.202104-0887OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome.PMID 34478357Read ↗

OBSTRUCTIVE APNEAS IN A MOUSE MODEL OF CONGENITAL CENTRAL HYPOVENTILATION SYNDROMESemantic proximity Read ↗

Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms.Semantic proximity Read ↗

Sleep-disordered Breathing in Newborn Mice Heterozygous for the Transcription Factor Phox2bSemantic proximity Read ↗

PHOX2B mutations and ventilatory control.Semantic proximity Read ↗

Central congenital hypoventilation syndrome: changing face of a less mysterious but more complex genetic disorder.Semantic proximity Read ↗

Congenital central hypoventilation syndrome.Semantic proximity Read ↗

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.Semantic proximity Read ↗

Congenital central hypoventilation syndrome: diagnosis and management.Semantic proximity Read ↗

Congenital central hypoventilation syndrome: a neurocristopathy with disordered respiratory control and autonomic regulation.Semantic proximity Read ↗

[Congenital central hypoventilation syndrome: paradigm shifts and future prospects].Semantic proximity Read ↗

Airway obstruction in two children with congenital central hypoventilation syndrome and review of the literature.Semantic proximity Read ↗

An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.