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Article

Ventilatory responses to hypercapnia and hypoxia in heterozygous c-ret newborn mice.

Respiratory physiology & neurobiology - 1 Aug 2002

Aizenfisz Sophie, Dauger Stéphane, Durand Estelle, Vardon Guy, Levacher Béatrice, Simonneau Michel, Pachnis Vassilis, Gaultier Claude, Gallego Jorge

Abstract excerpt

The c-ret proto-oncogene encodes a tyrosine-kinase receptor involved in survival and differentiation of neural crest cell lineages. Previous studies have shown that homozygous c-ret-/- mice die soon after birth and have impaired ventilatory responses to hypercapnia. Heterozygous c-ret +/- mice develop normally, but their respiratory phenotype has not been described in detail. We used whole-body flow...

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Source

Identifiers

PMID: 12126922
DOI: 10.1016/s1569-9048(02)00031-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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