Article

OBSTRUCTIVE APNEAS IN A MOUSE MODEL OF CONGENITAL CENTRAL HYPOVENTILATION SYNDROME

2021-02-16

Abstract excerpt

<h4>Rationale</h4> Congenital Central Hypoventilation Syndrome (CCHS) is characterized by life-threatening sleep hypoventilation, and is caused by PHOX2B gene mutations, most frequently the PHOX2B 27Ala /+ mutation, with patients requiring lifelong ventilatory support. It is unclear whether obstructive apneas are part of the syndrome. <h4>Objectives</h4> To determine whether Phox2b 27Ala /+ mice, which pre...

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Literature Corpus work: 2f2cf7b7-3e7b-5480-90a1-90b2189ca2e7
DOI: 10.1101/2021.02.15.431285

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