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Article

L1 augments cell migration and tumor growth but not β3 integrin expression in ovarian carcinomas

9 Feb 2005

Abstract excerpt

L1 is a neural cell adhesion molecule involved in cell migration, axon growth and guidance. Recent data have shown that L1 is overexpressed in ovarian and endometrial tumors and is associated with bad prognosis. How L1 promotes tumor progression is presently unknown. Here we show that L1 expression is predominantly confined to the invasive front of ovarian carcinomas. Overexpression of L1 in carcinoma cell lines...

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PMID: 15704102
DOI: 10.1002/ijc.20869

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