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Article

Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2012

Bondong S, Kiefel H, Hielscher T, Zeimet A G, Zeillinger R, Pils D, Schuster E, Castillo-Tong D C, Cadron I, Vergote I, Braicu I, Sehouli J, Mahner S, Fogel M, Altevogt P

Abstract excerpt

BACKGROUND: Overexpression of L1-cell adhesion molecule (L1CAM) has been observed for various carcinomas and correlates with poor prognosis and late-stage disease. In vitro, L1CAM enhances proliferation, cell migration, adhesion and chemoresistance. We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic...

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Identifiers

PMID: 22228447
DOI: 10.1093/annonc/mdr568

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